A briefly description of the scientific information related to bergamot flavonoids effect in glycaemia (blood glucose levels) are reported below.
- Mollace et al (2011). Hypolipemic and hypoglycaemic activity of bergamot polyphenols: From animal models to human studies. Fitoterapia 82 (2011) 309–316.
Description: double blind, placebo control, clinical trial carried out on 237 subjects with hypercholesterolemia and metabolic syndrome. Results have showed a significant reduction of blood glucose levels (as reported in results a “mean value of −18.9% under 500 mg BPF treatment (C1group) and −22.4% in C2 group) induced by bergamot juice extract intake.
- Gliozzi et al (2014). The Effect of Bergamot-Derived Polyphenolic Fraction on LDL Small Dense Particles and Non Alcoholic Fatty Liver Disease in Patients with Metabolic Syndrome. Advances in Biological Chemistry, 2014, 4, 129-137.
Description: clinical trial carried out on 107 patients suffering from metabolic and elevated fasting plasma glucose (or previously diagnosed type 2 diabetes). Bergamot flavonoid intake has induced a significant reduction of fasting plasma glucose from 118 ± 1.4 to 98 ± 0.8 mg/mL values (from Table 1).
- Parafati et al (2015). Bergamot polyphenol fraction prevents nonalcoholic fatty liver disease via stimulation of lipophagy in cafeteria diet-induced rat model of metabolic syndrome. Journal of Nutritional Biochemistry 26 (2015) 938 –948.
Description: in vivo (rats) model where hyperglycemia and metabolic syndrome have been induced by high fat diet (“cafeteria diet”) to simulate human “bad” diet habits and conditions. Bergamot flavonoid intake has induced a statistically different reduction of blood glucose levels in treated animals vs high fat diet (from Table 1).
Bionap srl, 06/December/2016
Dr Luisa Rizza